We will be reading a paper by Jonathan D. Gruber who is from Patricia Wittkopp’s lab. In the paper they compare Protein coding, cis, and trans mutations in S. cerevisiae that lead to an increase or decrease in the fluorescent of a reporter gene (YFP) http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1002497 .